Check out my new review out this month in Progress in Neuropsychopharmacology and Biological Psychiatry.
Here I review the literature examining pain induced changes in three brain regions integral to positive and negative emotional processing: the mesolimbic dopamine system, the amygdala, and the medial prefrontal cortex. I discuss the impact these adaptations may have on pain chronicity, intractability, and reward responsiveness.
What is clear from this literature is that chronic pain induces profound and important changes in brain regions beyond traditional “pain pathways”, and the sum of these changes contribute to the complex and multifaceted experience of chronic pain.
This article is part of a special issue on Chronic Pain and Psychiatric Disorders.
You can download the paper here or find it on PubMed.
I am beginning to wind up my projects at UCLA and transition to my new lab at the University of Alberta. The end (or beginning, depending on your perspective) is in sight! Continue reading
I’m beyond thrilled to announce that I have accepted a faculty position in the Department of Pharmacology at the University of Alberta. Continue reading
Check out our new review on the role of neuroinflammation in chronic pain and opioid dependence. It is included as part of a special issue on Addiction put out by Current Opinions in Behavioral Sciences. You can find our review here or download a PDF directly here. Continue reading
Its Neuroscience Christmas! We are headed down to San Diego for the Society for Neuroscience annual meeting next week. If you’ll be here as well, we’ve got some great posters to check out. Continue reading
Our microbiome project has been supported by the American Pain Society! Continue reading
Our new review, from current and former members of the Hatos Center for Neuropharmacology at UCLA, is now out in the journal Trends in Pharmacological Sciences. Continue reading
A peripheral nerve injury induced microglial activation widely throughout the brain, particularly in regions associated with pain and affect. Activation was most robust on the contralateral side – representing the injured afferent input. (From Taylor et al J Neurosci Res 2016)
Using morphological assessment and IBA-1 mRNA expression analyses, we assessed microglial activation throughout the brain in a mouse model of chronic pain. Continue reading
Here is Kevin Lee, a super undergraduate researcher in our lab, presenting his poster at the UCLA Undergraduate Research Day. Kevin and I have been working on a project comparing sustained versus intermittent morphine treatments on inflammation and negative affect. He’s produced some stellar data, and was recently awarded the Deans Prize in Research. Congrats, Kevin!
We will be presenting this data at the SFN Annual Meeting in San Diego, this fall. Come check it out!
In this review, which is the result of a productive collaboration with some fantastic female scientists, we discuss the relevance of striatal dopamine signaling in acute and chronic pain. Continue reading